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目的对比观察间隙与持续蓝光照射治疗新生儿病理性黄疸的效果。方法选取2015年1月—2016年4月就诊的新生儿病理性黄疸患儿136例,随机分为观察组和对照组各68例。两组均给予双歧杆菌或茵栀黄颗粒口服,2 g/次,3次/d。同时,对照组行持续蓝光照射治疗,照射18 h,停6 h。观察组行间隙蓝光照射治疗,照射4~6 h,中断2~4 h,如此循环。以上疗程均3~5 d。分别于治疗前后检测两组血清间接胆红素水平,对比两组总有效率,观察记录两组治疗过程中不良反应发生情况。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果观察组治疗前后血清间接胆红素分别为(269.2±20.4)、(150.5±16.9)μmol/L,对照组分别为(254.3±21.6)、(183.4±17.1)μmol/L。治疗后观察组血清间接胆红素低于对照组,比较差异有统计学意义(P<0.05)。观察组总有效率为98.5%,对照组为91.2%,两组比较差异无统计学意义(P>0.05)。观察组并发症发生率为7.69%,对照组为34.62%,两组比较差异有统计学意义(P<0.05)。结论与持续蓝光照射比较,间隙蓝光照射可有效治疗新生儿病理性黄疸,且并发症少。
Objective To compare the effects of intermittent and continuous blue light irradiation on neonatal pathological jaundice. Methods From January 2015 to April 2016, 136 cases of neonatal pathological jaundice were randomly divided into observation group (68 cases) and control group (68 cases). Both groups were given Bifidobacterium or Yinzhihuang granules orally, 2 g / time, 3 times / d. At the same time, the control group continued blue radiation treatment, irradiation 18 h, stop 6 h. Observation group interstitial blue light irradiation treatment, irradiation 4 ~ 6 h, interrupted 2 ~ 4 h, so the cycle. The above treatment are 3 ~ 5 d. The level of indirect bilirubin in serum was detected before and after treatment. The total effective rate was compared between the two groups. The incidence of adverse reactions in the two groups were observed and recorded. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The levels of indirect bilirubin in the observation group before and after treatment were (269.2 ± 20.4) and (150.5 ± 16.9) μmol / L, respectively, and those in the control group were (254.3 ± 21.6) and (183.4 ± 17.1) μmol / L, respectively. After treatment, the serum indirect bilirubin in the observation group was lower than that in the control group, with significant difference (P <0.05). The total effective rate was 98.5% in the observation group and 91.2% in the control group, with no significant difference between the two groups (P> 0.05). The incidence of complications in the observation group was 7.69% and that in the control group was 34.62%. There was significant difference between the two groups (P <0.05). Conclusion Compared with continuous blue light irradiation, interstitial blue light irradiation can effectively treat neonatal pathological jaundice with less complications.