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为了解华石斛(Dendrobium sinense)的化学成分,采用多种柱色谱技术从其全草乙醇提取液中分离纯化了10个化合物,经波谱分析分别鉴定为:鼓槌石斛素(1)、2′,4′-二羟基查尔酮(2)、2,5,7-三羟基-4-甲氧基-9,10-二氢菲(3)、4,7-二羟基-2,3-二甲氧基-9,10-二氢菲(4)、2,5-二羟基-3,4-二甲氧基-9,10-二氢菲(5)、2,7-二羟基-3,4,6-三甲氧基-9,10-二氢菲(6)、(E)松柏醛(7)、反式对羟基肉桂酸酯(8)、对羟基苯丙酸甲酯(9)和十二元内环酯(10)。所有化合物均为首次从华石斛中分离得到,其中化合物2、6、7和10对乙酰胆碱酯酶具有一定的抑制活性。
In order to understand the chemical constituents of Dendrobium sinense, 10 compounds were isolated and purified from the ethanol extracts of Allium sativus by various column chromatographies and identified as: Dendrobium sinensis (1), 2 ’ Dihydroxy chalcone (2), 2,5,7-trihydroxy-4-methoxy-9,10-dihydrophenanthrene (3), 4,7-dihydroxy- Dihydrophenanthrene (4), 2,5-dihydroxy-3,4-dimethoxy-9,10-dihydrophenanthrene (5), 2,7-dihydroxy- Trimethoxy-9,10-dihydrophenanthrene (6), (E) coniferyl aldehyde (7), transhydroxycinnamate (8), methylparaben ) And twelve membered endocyclic ester (10). All the compounds were isolated from Dendrobium for the first time, and compounds 2, 6, 7 and 10 showed some inhibitory activity against acetylcholinesterase.