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目的:探讨HBsAg阳性妊娠期妇女HBV血清标志物模式、HBV DNA载量、ALT、AST与母婴传播阻断效果之间的关系，评估发生母婴传播的风险。方法:选取2012年7月至2015年6月参加乙型肝炎母婴传播阻断项目的657例HBsAg阳性母亲及662例新生儿（含5对双胞胎）为研究对象，检测孕妇的HBV血清标志物、HBV DNA载量及肝功能指标，在新生儿7月龄时测定HBV血清标志物和HBV DNA，以探讨新生儿感染HBV情况与母亲孕晚期相关检测指标的关系。结果:HBsAg/HBeAg双阳性组孕妇HBV DNA载量、ALT和AST异常比例显著高于HBeAg阴性组孕妇（HBV DNA:1×10n 8vs. 850 IU/mL, n Z=-21.554, n P2×10n 5 IU/mL者，需要密切观察病毒载量水平，并给予孕晚期抗病毒治疗，以降低肝损伤和母婴传播的发生风险。n “,”Objective:To explore the relationship between HBV serum marker (HBV-M) patterns, HBV DNA load, ALT, AST and blocking effect of mother-to-child transmission in pregnant women with positive HBsAg, and to evaluate the risk of mother-to-child transmission.Methods:A total of 657 mothers with positive HBsAg and 662 newborns (including 5 pairs of twins) who participated in the project of blocking mother-to-child transmission of hepatitis B were selected from July 2012 to June 2015. HBV-M, HBV DNA load and liver function indexes were detected in pregnant women. HBV-M and HBV DNA were detected in newborns at the age of 7 months, in order to explore the relationship between neonatal HBV infection and related laboratory indexes of late pregnancy.Results:HBV DNA load, the proportions of abnormal ALT and AST in HBsAg/HBeAg positive group were significantly higher than those in HBeAg negative group (HBV DNA: 1×10n 8vs. 850 IU/mL, n Z=-21.554, n P2×10n 5 IU/mL, which can reduce the risk of liver function damage and mother-to-child transmission.n