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人类疱疹病毒 6型 (humanherpesvirus 6,HHV 6)是一种常见的病毒 ,与多种人类疾病有关。由于研究过程所采取方法不同 ,对于白血病病人感染HHV 6情况的报道也不一致。本研究首次运用巢式PCR检测了 38例髓系白血病病人外周血单个核细胞中的HHV 6DNA ,其中急性髓性白血病 (AML) 30例和慢性粒细胞白血病 (CML) 8例。结果显示 :与正常对照HHV 6的DNA检出率相比 ,AML患者的阳性率明显降低 ,而CML中则无明显异常 ,其临床意义有待进一步探讨
Human herpesvirus 6 (HHV 6) is a common virus that is associated with various human diseases. Due to different methods used in the research process, reports of HHV 6 infection in leukemia patients are also inconsistent. This study was the first to use nested PCR to detect HHV 6 DNA in peripheral blood mononuclear cells in 38 patients with myeloid leukemia, including 30 cases of acute myeloid leukemia (AML) and 8 cases of chronic myelogenous leukemia (CML). The results showed that: compared with the normal control HHV 6 DNA detection rate, the positive rate of AML patients was significantly reduced, but no significant abnormalities in CML, its clinical significance to be further explored