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头孢唑肟(CZX)为第三代头孢菌素类抗生素,CZX对革蓝氏阳性及阴性细菌均有抗菌作用,目前在临床上已广泛应用。CZX在治疗神经外科开颅术后脑膜有炎症的病例中已确认其有效。然而,一般的头孢菌素类抗生素,其脂溶性低,易于离子化,不易通过血脑屏障,故在颅内非炎症时药物向脑脊液的移行情况不好,本文报道CZX作为开颅术后预防感染用药时向脑脊液移行的动态变
Ceftizoxime (CZX) is the third generation cephalosporin antibiotics, CZX against Gram-positive and negative bacteria have antibacterial effect, is currently widely used in clinical practice. CZX has been shown to be effective in the treatment of inflammation of the meninges following neurosurgical craniotomy. However, the general cephalosporin antibiotics, its low fat solubility, easy ionization, not easy to cross the blood-brain barrier, so when the intracranial non-inflammatory drug migration to the cerebrospinal fluid is not good, this report CZX as craniotomy after prevention Infection medication to cerebrospinal fluid migration of dynamic change