大量的工作已经证明,内源性阿片样物质在中枢神经系统中广泛分布,并具有十分复杂的生理功能。随着这方面工作深入,对于脑内是否存在其对抗性物质已引起人们注意。已经从脑内分离提取得到了某些具有对抗阿片活性的未知物质,同时也发现了某些已知的神经化学物质,特别是神经肽,也可不同程度地调节阿片样物质的活性。 Extensive work has demonstrated that endogenous opioids are widely distributed in the central nervous system and have very complex physiological functions. With the deepening of work in this area, attention has been drawn to whether or not there is any antagonistic substance in the brain. Some unknown substances that have anti-opiate activity have been isolated and extracted from the brain. Some known neurochemicals, especially neuropeptides, have also been found, and the opioid activity can be regulated to varying degrees.