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观察促甲状腺素释放激素（ＴＲＨ）在体内和体外对小鼠脾细胞产生ＩＦＮ和ＩＬ－２的影响。结果表明，正常小鼠每天腹腔注射ＴＲＨ０．２μｇ／只，共１０ｄ，其脾细胞受ＣｏｎＡ刺激产生的ＩＦＮ和ＩＬ－２产量无显著增高（Ｐ＞０．０５）；对氢化可的松处理的免疫抑制小鼠，加用以上剂量ＴＲＨ后，其脾细胞产生ＩＦＮ和ＩＬ－２的能力明显提高（Ｐ＜０．０１）。在体外用ＴＲＨ孵育小鼠脾细胞，其浓度在０．００３９～１（１０－１０ｍｏｌ／Ｌ）时可显著提高ＣｏｎＡ诱生的脾细胞ＩＦＮ和ＩＬ－２的产量，且产量与ＴＲＨ的浓度呈正相关；但高于此浓度时，其产量与ＴＲＨ浓度呈负相关，呈现与剂量相关的双相调节作用。提示ＴＲＨ的免疫调节机理之一是通过影响这些细胞因子的产生。
To observe the effects of thyrotropin-releasing hormone (TRH) on the production of IFN and IL-2 in mouse splenocytes in vitro and in vivo. The results showed that the production of IFN and IL-2 in splenocytes stimulated by ConA was not significantly increased (P> 0.05). The effect of hydrocortisone-treated Immunosuppressed mice, with the above doses of TRH, the ability of spleen cells to produce IFN and IL-2 was significantly increased (P <0.01). In vitro incubation of mouse spleen cells with TRH significantly increased the production of IFN and IL-2 by ConA-induced splenocytes at a concentration of 0.0039-1 (10-10 mol / L), and the production was positively correlated with the concentration of TRH However, above this concentration, the production was negatively correlated with TRH concentration, showing dose-dependent biphasic regulation. It is suggested that one of the mechanisms of TRH immunomodulation is through influencing the production of these cytokines.