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  5. Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phos

Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phos

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：jazz988
【摘 要】
：
A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cell
【作 者】
：
Xiao Zhong Fu Sai Hong Jiang J 
【机 构】
：
School of Pharmacy,State Key Laboratory of Drug Research,Shanghai Fudan-Yueda Bio-Tech Co. Ltd.
【出 处】
：
中国化学快报（英文版）
【发表日期】
：
2004年期
【关键词】
：
Acyclic nucleoside phosphonates L-Amino acid Prodrug Anti-HBV activity 
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论文部分内容阅读
A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 μmol/L and 2530 μmol/L, respectively.(C) 2007 Yu She Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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