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目的:探讨急性脑梗死致心脏损伤患者血清缺血修饰白蛋白的变化。方法:采用白蛋白钴结合试验检测80例单纯性急性脑梗死患者(单纯性脑梗死组)、45例急性脑梗死引起心脏损伤患者(混合性脑梗死组)和759例急性心肌缺血患者(心肌缺血组)血清缺血修饰白蛋白水平,并同时进行心肌肌钙蛋白I和心电图检测。同期检测875例健康体检者(对照组)血清缺血修饰白蛋白。结果:血清缺血修饰白蛋白水平和阳性率在脑梗死组及心肌缺血组均高于正常组(P<0.05),混合性脑梗死组高于单纯性脑梗死组(P<0.05),混合性脑梗死组与心肌缺血组比较差异无统计学意义(P>0.05)。混合性脑梗死组心肌肌钙蛋白I水平高于单纯性脑梗死组(P<0.05)。急性冠状动脉综合征患者首诊缺血修饰白蛋白、心电图、心肌肌钙蛋白I的阳性率分别为80.4%、75.4%和58.7%;缺血修饰白蛋白与心电图或与心肌肌钙蛋白I联合检测,其敏感性分别为93.9%和87.9%。结论:观察脑梗死患者血清缺血修饰白蛋白水平,有助于急性脑梗死所致心脏损伤的早期发现。
Objective: To investigate the changes of serum albumin in patients with heart injury caused by acute cerebral infarction. Methods: Eighty patients with simple acute cerebral infarction (simple cerebral infarction group), 45 patients with acute myocardial infarction (MCI) and 759 patients with acute myocardial ischemia Myocardial ischemia group) Serum ischemia modified albumin levels, and cardiac troponin I and ECG testing. In the same period, 875 healthy subjects (control group) were serum-modified albumin. Results: The level of serum modified albumin and the positive rate in cerebral infarction group and myocardial ischemic group were significantly higher than those in normal group (P <0.05), and those in mixed cerebral infarction group were higher than those in simple cerebral infarction group (P <0.05) There was no significant difference between mixed cerebral infarction group and myocardial ischemia group (P> 0.05). Cardiac troponin I levels in mixed cerebral infarction group were higher than those in simple cerebral infarction group (P <0.05). The first diagnosis of acute coronary syndrome patients with ischemic-modified albumin, electrocardiogram, cardiac troponin I positive rates were 80.4%, 75.4% and 58.7%; ischemia-modified albumin and ECG or cardiac troponin I joint Testing, the sensitivity was 93.9% and 87.9%. Conclusion: To observe the level of serum albumin in patients with cerebral infarction is helpful to the early detection of cardiac injury caused by acute cerebral infarction.