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目的探讨奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的临床疗效。方法随机将在鹤岗矿业集团公司总医院消化内科治疗的48例肝硬化上消化道出血的患者分成两组,观察组与对照组,观察组24例患者应用奥曲肽联合普萘洛尔进行治疗,对照组24例患者单独应用奥曲肽进行治疗,比较两组患者的临床疗效及不良反应。结果观察组的显效率明显高于对照组,差异有统计学意义(P<0.01);观察组的无效率明显低于对照组,差异有统计学意义(P<0.01)。观察组有1例患者出现心律减慢,眩晕,调整剂量后消失,其他无明显不良反应发生。对照组无明显不良反应发生。结论奥曲肽联合普萘洛尔可明显提高肝硬化上消化道出血临床疗效,无明显不良反应,可在临床中推广应用。
Objective To investigate the clinical efficacy of octreotide combined with propranolol in the treatment of upper gastrointestinal bleeding in cirrhosis. Methods Forty-eight patients with upper gastrointestinal hemorrhage who underwent gastroenterology in Hegang Mining Group General Hospital were randomly divided into two groups: observation group and control group. In the observation group, 24 patients were treated with octreotide and propranolol, Twenty-four patients in the control group were treated with octreotide alone. The clinical efficacy and adverse reactions of the two groups were compared. Results The apparent efficiency of the observation group was significantly higher than that of the control group (P <0.01). The inefficiency of the observation group was significantly lower than that of the control group (P <0.01). One patient in the observation group had a slow heartbeat, dizziness, disappeared after adjusting the dose, and no other adverse reaction occurred. No significant adverse reactions occurred in the control group. Conclusion Octreotide combined with propranolol can significantly improve the clinical efficacy of cirrhosis with upper gastrointestinal bleeding, no obvious adverse reactions, which can be widely applied in clinic.