SLE是一多系统发生炎症的免疫性疾病,约50％～80％病人出现肾炎症状,几乎全部有肾组织学改变。以肾炎表现为主要特征称为狼疮性肾炎(lupus nephritis,LN)。其发病原因及机制未完全明了,现将近年新的研究进展分述于下: 1 发病原因与机制 1.1 遗传素质:SLE病人的近亲发病率为4％～5％,明显高于人群发病率0.4％～5％。单卵孪生子中两人均发本病者高达25％～70％,而双卵孪生子中则仅3％,与兄弟姊妹中的发病率相同。在美国,黑人的发 SLE is a multi-systemic inflammatory immune disease, about 50% to 80% of patients with nephritis symptoms, almost all renal histological changes. Nephritis as the main feature is called lupus nephritis (LN). The pathogenesis and mechanism is not entirely clear, now in recent years, new research progress is described in the following: 1 pathogenesis and mechanism of 1.1 genetic quality: SLE patients in the incidence of 4% to 5%, significantly higher than the incidence of 0.4 % ~ 5%. Both single-oviparous twins developed as high as 25% to 70% of the disease, compared with only 3% of double-egg twins, the same rate as in siblings. In the United States, black hair