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为探讨二硫化碳（ＣＳ_２）对大鼠的肾脏毒性，３个染毒组分别以５０，２５０，１２５０ｍｇ／ｍ￣３的浓度静式吸入ＣＳ_２，每天２ｈ，每周６天，连续８周，并与对照组比较。结果：１、各染毒组尿γ－ＧＴ、ＡＫＰ活性、尿β_２－ＭＧ含量，大、中剂量组尿ＬＤＨ活性、尿Ａｌｂ含量，以及大剂量组尿ＩｇＧ、总蛋白含量、血ＢＵＮ含量均较对照组显著增高；２、光镜检查发现肾小管上皮细胞浊肿、空泡变性、肾小球肿大；电镜下见基底膜紊乱、线粒体肿胀、嵴断裂等；３、肾皮质小管中ＡＫＰ、ＡＴＰａｓｅ、ＳＤＨ、ＡＮＡＥ酶活性下降，以ＡＫＰ，ＳＤＨ活性下降最为明显。
To investigate the renal toxicity of carbon disulfide (CS_2) in rats, the three exposure groups were inhaled CS_2 at a concentration of 50, 250 and 1250 mg / m ~ 3 respectively for 2 hours a day, 6 days a week for 8 weeks, Comparison of the control group. Urine γ-GT, AKP activity, urinary β_2-MG content, urinary LDH activity and urinary Alb content in large and medium dose groups and urinary IgG, total protein content and blood BUN content in high dose group Which was significantly higher than that of the control group. (2) The renal tubular epithelial cells were found to have turbidity, vacuolar degeneration and glomerulus enlargement by light microscopy. The basal membrane disordered, swelling of mitochondria, , ATPase, SDH, ANAE activity decreased, with AKP, SDH activity decreased the most obvious.