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目的和方法 :本文试图证明 :ＮＦ -ＫＢ信号通路的激活可能介导了过氧化氢 (Ｈ2 Ｏ2 )所致的心肌细胞凋亡 ,实验用体外培养的新生Ｗｉｓｔａｒ大鼠心肌细胞 ,随机分为三组 :1 正常对照组 ( 37℃ ,3ｈ) ;2 Ｈ2 Ｏ2 ( 1ｍｍｏｌ/Ｌ)损伤组 ( 37℃ ,2 4ｈ) ;3 热休克预处理 ( 4
PURPOSE AND METHODS: This study was designed to demonstrate that activation of NF-κB signaling pathway may mediate cardiomyocyte apoptosis induced by hydrogen peroxide (H2O2). The cultured neonatal Wistar rat cardiomyocytes were randomly divided into three groups Group 1: normal control group (37 ℃, 3h); 2 H2O2 (1mmol / L) injury group (37 ℃, 24 h); 3 heat shock pretreatment