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目的探讨C-反应蛋白联合B型钠尿肽(BNP)指标评估先天性心脏病肺部感染患儿心功能的临床应用价值。方法收集2010年1月-2013年8月诊断为先天性心脏病合并肺部感染患儿50例为患儿组,以健康儿童50名作为对照组,监测BNP以及C-反应蛋白的变化,采用SPSSl5.0软件对收集的资料进行统计分析。结果先天性心脏病合并肺部感染患儿BNP与C-反应蛋白指标分别为(522.2±45.3)pg/ml、(15.2±8.3)mg/L,高于健康组儿童的(25.4±8.4)pg/ml、(4.3±1.1)mg/,两组比较差异有统计学意义(P<0.01);50例患儿入院后给予积极治疗干预,治疗后BNP与C-反应蛋白指标分别下降至(37.4±8.4)pg/ml、(8.8±1.3)mg/L,差异有统计学意义(P<0.01);不同心功能患儿BNP与C-反应蛋白指标组间比较,差异均有统计学意义(P<0.05),心功能越差患儿的BNP指标和C-反应蛋白指标越高;对不同心功能分级与BNP、C-反应蛋白进行相关性分析,显示之间具有正相关,其中BNP与心功能之间相关性(r=0.81,P<0.01),C-反应蛋白与心功能相关性(r=0.43,P<0.05)。结论临床根据C-反应蛋白联合BNP评价先心病肺部感染评价心功能具有较强的可靠性,在临床上应该给予重视。
Objective To investigate the clinical value of C-reactive protein combined with B-type natriuretic peptide (BNP) in assessing cardiac function in children with pulmonary infection of congenital heart disease. Methods Fifty children diagnosed as congenital heart disease complicated with pulmonary infection from January 2010 to August 2013 were selected as the children group and 50 healthy children as the control group to monitor the changes of BNP and C-reactive protein. SPSSl5.0 software to collect data for statistical analysis. Results The levels of BNP and C-reactive protein in children with congenital heart disease and pulmonary infection were (522.2 ± 45.3) pg / ml and (15.2 ± 8.3) mg / L, respectively, higher than those in healthy children (25.4 ± 8.4) pg / ml, (4.3 ± 1.1) mg /, the difference between the two groups was statistically significant (P <0.01); 50 patients were given active treatment after admission intervention, BNP and C-reactive protein index decreased to 37.4 ± 8.4) pg / ml and (8.8 ± 1.3) mg / L, respectively, with statistical significance (P <0.01). There was significant difference between BNP and C-reactive protein in children with different cardiac function P <0.05). BNP and C-reactive protein were higher in children with worse heart function. Correlation analysis showed that there was a positive correlation between BNP and C-reactive protein in different cardiac function classification. Among them, BNP and (R = 0.81, P <0.01), and the correlation between C-reactive protein and cardiac function (r = 0.43, P <0.05). Conclusion Clinical evaluation of C-reactive protein combined with BNP in the evaluation of pulmonary heart disease with congenital heart disease has a strong reliability and should be given great attention in clinic.