论文部分内容阅读
2年前,澳大利亚就注意到有关与氟氯唑青霉素相关的胆汁瘀积性肝炎的报道大大增加.不久前,瑞典也报道了12例.目前,氟氯唑青霉素已被广泛应用于临床,其处方量从1983年的12136张上升至1990年的100万张.根据澳大利亚有害药物反应顾问委员会(ADRAC)收集的资料表明,随该药处方量的增加,其肝损药物毒性也同样增加.到1991年7月已报告131例.根据临床医师、牙科医师和药剂师报告的有害药物反应,ADRAC将其分为以下4类:肯定、很可能、可能和不可能.作者对已报告的131例中的51例作了分析,氟氯唑青霉素是唯一的可疑药物.51例中女性多于男性(女∶男为34∶17),平均年龄58岁,平均治疗时间为14.9天,从开始用药到发病的潜伏期为22.6天,每日平均剂
Two years ago, Australia noticed a tremendous increase in reports of cholestatic hepatitis associated with fluconazole.And not long ago, 12 cases were reported in Sweden.Currently, fluconazole has been widely used clinically The prescription increased from 12,136 in 1983 to 1 million in 1990. According to data collected by the Australian Advisory Council on Adverse Drug Reactions (ADRAC), the toxicity of hepatic impairment drugs also increased with increasing prescriptions 131 cases were reported in July 1991. According to reports of adverse drug reactions by clinicians, dentists and pharmacists, ADRAC classifies them into the following four categories: positive, probable, probable and impossible. The authors reported 131 cases In the 51 cases were analyzed, the only suspected flucloxacillin drug.In 51 cases, more women than men (female: male 34:17), mean age 58 years, the average treatment time was 14.9 days, from the beginning of medication The onset of the incubation period was 22.6 days, the average daily dose