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本文用28只犬,分别作单纯胆汁反流、单纯胰液反流、胆-胰液共同反流、胆-胰液断流实验模型,并与对照组作比较.术后6个月,各组均作胃镜观察,胃粘膜活检分别作光镜、扫描和透射电镜观察,发现胆汁或胆-胰液反流区胃粘膜显示有炎症、糜烂、萎缩以及肠腺化生;上皮细胞、壁细胞和G细胞内细胞器肿胀、扩张或减少.作者认为胆汁或胆-胰液反流入胃,是碱性反流性胃炎的主要致病因素,单纯胰液对胃粘膜损害较小,扫描和透射电镜观察早期肠化生优于光镜.
In this paper, 28 dogs, respectively, for simple bile reflux, simple pancreatic reflux, biliary-pancreatic juice common reflux, gallbladder-pancreatic fluid flow model and compared with the control group.After 6 months, the groups were made Gastroscopy and gastric mucosal biopsies were observed by light microscopy, scanning and transmission electron microscopy, respectively, and found that the gastric mucosa of bile or bile-pancreatic reflux region showed inflammation, erosion, atrophy and gut metaplasia; epithelial cells, parietal cells and G cells Organelles swelling, expansion or decrease.The author believes that the bile or gallbladder - pancreatic fluid reflux into the stomach, is the main causative agent of alkaline reflux gastritis, simple pancreatic juice less damage to the gastric mucosa, scanning and transmission electron microscopy early intestinal metaplasia In the light of the mirror.