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目的研究急性胰腺炎发病及治愈后患者的免疫功能变化。方法检测31例急性胰腺炎患者发病后和治愈后T细胞亚群、IgA、IgM、IgG抗体和补体C3、C4,进行前后对比分析并与正常对照组对比分析。结果急性胰腺炎发病后其T淋巴细胞亚群中总T细胞、CD4+细胞和CD4+/CD8+比值均下降;血清IgA、IgG、IgM、补体C3、C4水平有不同程度的下降,其中以重症急性胰腺炎最明显;随着疾病的治愈,机体免疫功能逐步恢复,上述免疫学指标也大都能恢复到正常水平。结论急性胰腺炎患者存在不同程度的免疫功能损害,尤其以重症急性胰腺炎明显,其与疾病的发展和转归相互影响、相互作用,在急性胰腺炎的治疗中应重视免疫功能的变化。
Objective To study the changes of immune function in patients with acute pancreatitis after onset and cure. Methods T-cell subgroups, IgA, IgM, IgG antibodies and complement C3 and C4 were detected in 31 patients with acute pancreatitis after onset and after treatment, and compared with the normal control group. Results The ratio of total T cells, CD4 + cells and CD4 + / CD8 + in T lymphocyte subsets decreased after acute pancreatitis. The levels of serum IgA, IgG, IgM, C3 and C4 were decreased to some extent. Severe acute pancreatitis Inflammation is the most obvious; with the cure of the disease, the immune function of the body gradually restored, most of the above immunological indicators can be restored to normal levels. Conclusion Patients with acute pancreatitis have different degrees of immune dysfunction, especially in patients with severe acute pancreatitis. They interact with the development and outcome of the disease and interact with each other. In the treatment of acute pancreatitis, the immune function should be emphasized.