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系统性红斑狼疮 (systemiclupuserythematosus,SLE)是多器官受累的自身免疫病的原型 ,免疫学异常突出表现在多种自身抗体形成并伴有相应的免疫损伤[1] 。在自身抗体中 ,以抗核抗体 (antinuclearantibodies ,ANA)具有重要的诊断意义和一定的致病作用[2 ] 。但是驱动这些抗核抗体
Systemic lupus erythematosus (systemic lupus erythematosus, SLE) is a prototype of multiple organ-involved autoimmune diseases, immunological abnormalities highlighted in the formation of a variety of autoantibodies with the corresponding immune damage [1]. Among the autoantibodies, anti-nuclear antibodies (antinuclearantibodies, ANA) has important diagnostic significance and a certain pathogenic role [2]. But drives these antinuclear antibodies