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二羧乙基锗倍半氧物(Dicarboxyethyl GermaniumSesquioxide,DEG)是人工合成的有机锗化合物。它能对抗Shay幽门结扎性溃疡的形成,使胃液中PGE_2含量增加,胃蛋白酶活性和游离酸度明显降低。DEG还能对抗消炎痛型,五肽胃泌素型和酒精型溃疡的形成,促进醋酸型溃疡的愈合,但对应激型和利血平型溃疡无对抗作用。DEG的主细胞分泌功能比对照组明显减弱。实验结果表明,DEG的抗溃疡作用可能与增加胃内PGE_2含量、抑制胃液分泌和促进蛋白质合成有关。
Dicarboxyethyl Germanium Sesquioxide (DEG) is a synthetic organic germanium compound. It can antagonize the formation of Shay pyloric ligation ulcer, so that the content of PGE2 in gastric juice increased, pepsin activity and free acidity decreased significantly. DEG can also antagonize the formation of indomethacin, pentagastrin type and alcohol type ulcer, promote the healing of acetic acid type ulcer, but no antagonism to stress type and reserpine type ulcer. The main cell secretory function of DEG was obviously weaker than the control group. The experimental results show that the anti-ulcer effect of DEG may be related to increasing the content of PGE 2 in the stomach, inhibiting gastric secretion and promoting protein synthesis.