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日本的Suzuki等人通过Scatchard分析及等电聚焦等方法对RU486给药后妊娠大鼠Wistar的子宫内膜甾体受体进行了研究,以了解RU486引起的流产机制。作者给妊娠和非妊娠大鼠经皮下注射给药,剂量为每公斤体重5和10mg。给药后24小时取血和子宫,然后测定子宫细胞浆内孕酮受体(PR),雌激素受体(ER)和雄激素受体(AR)的浓度以及血浆中甾体激素的浓度。非妊娠大鼠中,PR的总结合部位(B_(max))在给药后下降,ER的总结合部位与对照组比
Suzuki, who in Japan through the Scatchard analysis and isoelectric focusing and other methods RU486 administration of pregnant rats Wistar endometrial steroid receptors were studied to understand RU486-induced abortion mechanism. The authors administered subcutaneous injections to pregnant and non-pregnant rats in doses of 5 and 10 mg / kg body weight. Blood and uterus were taken 24 hours after the administration, and the concentrations of progesterone receptor (PR), estrogen receptor (ER) and androgen receptor (AR), and plasma steroid hormone in uterine cytoplasm were measured. In non-pregnant rats, the total binding site of PR (B max) decreased after administration, the total binding site of ER was