目的　为了实现消灭脊髓灰质炎(脊灰)目标,制定了一系列的策略。方法　通过健康教育,常规、强化免疫,实行AFP监测。结果　全省在1993年7月后已连续5年无脊灰野病毒感染病例发生。OPV常规免疫接种率达到97.93%,发病率较前降低了80.93%,削平了季节高峰,打破了流行周期,缩小了流行范围,1993年发病市县较1989年减少了81.33%。1993～1997年实施了4次强化免疫,消除了免疫空白点,使人群形成了牢固的免疫屏障,抗体几何平均滴度达到1∶400以上。1991年建立脊灰监测系统,非脊灰AFP报告率从“0”提高到1.27/10万,双份标本采集率从“0”提高到87.10%以上,病毒分离阳性率由23.07%提高到34.80%,阳性标本经国家脊灰实验室鉴定均未发现野毒株。健康教育收到了显著效果,家长对服苗知识提高了75个百分点。结论　本研究表明,海南省消灭脊灰策略取得了显著的效果,为控制和消灭疫苗针对疾病提供了宝贵的经验。 Aim To achieve the goal of eradicating poliomyelitis (polio), a series of strategies have been developed. Methods AFP surveillance was conducted through health education, routine and intensive immunization. Results The province had no cases of poliovirus infection for five consecutive years after July 1993. The routine immunization rate of OPV reached 97.93%, the incidence rate was reduced by 80.93% compared with the previous one, which flattened the season peak, broke the epidemic cycle and narrowed the epidemic range. In 1993, the incidence rate in cities and counties decreased by 81.33% compared with that in 1989. From 1993 to 1997, four times of intensive immunization were carried out to eliminate the immune blank and make the population form a solid immune barrier. The average geometric mean antibody titer reached 1: 400. In 1991, the poliovirus monitoring system was established. The reported rate of non-polio AFP was increased from “0” to 1.27 / 100,000 and the double-specimen collection rate increased from “0” to above 87.10%. The positive rate of virus isolation increased from 23.07% to 34.80 %, Positive specimens were identified by the national polio laboratory were not wild strains. Health education has received significant results, parents knowledge of clothing increased by 75 percentage points. Conclusion This study shows that the strategy of polio eradication in Hainan Province has achieved remarkable results and provided valuable experience in controlling and eliminating vaccines against diseases.