在眼球的发育过程中,Wnt(wingless-type MMTV integration site family members)信号转导通路起着重要作用,晶状体上皮细胞的分化以及晶状体的发育与Wnt信号转导通路有着密切的关系~([1])。在脊椎动物晶状体的早期发育阶段,经典Wnt信号转导通路通过抑制视泡和表面外胚层的形成来调节晶状体的发育~([2-4]),随后通过影响晶状体上皮细胞和晶状体 Wnt (wingless-type MMTV integration site family members) signal transduction pathway plays an important role in the development of the eye. The differentiation of lens epithelial cells and the development of lens are closely related to the Wnt signal transduction pathway ([1 ]). In the early stages of vertebrate lens development, the canonical Wnt signaling pathway regulates the development of the lens by inhibiting the formation of optic vesicles and epidermal ectoderm ([2-4]), and subsequently by affecting lens epithelial cells and lens