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在许多炎症情况下C-反应蛋白(CRP)是一个敏感的急性期反应物,血清中的浓度非特异性增加。这种应答显然是由单核细胞产生了白细胞介素-1的结果,因此CRP是这种免疫应答的一个间接指标。在移植排斥发炎中这种应答的增加程度是有意义的,因为这种物质的测定对排斥发作的检测和监控可能是有益的。作者报告了免疫抑制对血清CRP浓度的影响,并评价了两种不同的同种器官移植后连续测定CRP对判断排异反应发生的作用。研究的44例病人(男28,女16,平均年龄33.6岁)中,其中肾移植26例,供肾者为健在的亲属,用一个至全部单倍型
C-reactive protein (CRP) is a sensitive acute phase response in many inflammatory conditions, with a nonspecific increase in serum concentration. This response is apparently the result of interleukin-1 production by monocytes and therefore CRP is an indirect indicator of this immune response. The extent of this increase in transplant rejection is of interest, as the determination of this substance may be beneficial in the detection and monitoring of rejection episodes. The authors report the effect of immunosuppression on serum CRP concentrations and evaluate the role of continuous determination of CRP in determining rejection after two different organs of the same organ type. Of the 44 patients studied (male 28, female 16, mean age 33.6 years), 26 were renal transplant recipients who were healthy relatives, with one to all haplotype