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目的：探讨精神分裂症患者糖代谢异常发生状况及其相关影响因素。方法对152例首发精神分裂症患者治疗过程中的糖代谢指标进行监测，随访24个月，统计患者治疗第1个月、3个月、12个月及24个月时糖代谢异常发生状况，并分析其影响因素。结果本组患者随访24个月时糖代谢异常发生率为36．18％，其中空腹血糖损害为17．11％、糖耐量减退为10．53％、糖尿病为8．55％；糖代谢异常发生率随着服药时间的延长呈现逐渐增加趋势；Logistic 回归分析显示，高龄、肥胖及病程均是发生糖代谢异常的危险因素（P＜0．05）。结论精神分裂症患者可出现糖代谢异常症状，且糖代谢异常发生率随着服药时间的延长呈现逐渐增加趋势，其发生可能与患者的年龄、病程、体质量有关。“,”Objective To explore the development and related influencing factors of abnormal glucose me‐tabolism in schizophrenia patients .Methods Glycometabolic indexes during treatment were detected in 152 first‐episode schizophrenics ,followed up for 24 months ,developments of abnormal glucose metabolism added up in the 1st ,3rd ,12th and 24th month of treatment ,and influencing factors analyzed .Results The incidence of abnormal glucose metabolism was 36 .18% in the 24th month of follow‐up ,in which impaired fasting glucose 17 .11% ,impaired glucose tolerance 10 .53% and diabetes 8 .55% ;the incidence of abnor‐mal glucose metabolism increased gradually along with the prolongation of medication time ;Logistic re‐gression analysis showed that advanced age ,obesity and course of disease were risk factors of abnormal glucose metabolism (P< 0 .05) .Conclusion Schizophrenia patients could present abnormal glucose me‐tabolism symptoms ,the incidence of abnormal glucose metabolism increases gradually along with the pro‐longation of medication time ,and the development of abnormal glucose metabolism could be related to age , course of disease and body mass .