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亚硝基甲基脲(NMU)是一种N-亚硝基化合物,食物中有微量存在,曾报导也可能在人体胃中通过内源性形成。在实验条件下,N-亚硝基化合物显示出有明显的致癌、致畸、致突变等生物学特征,被认为是环境中一种潜在的有毒因子。本文作者用[~8H-甲基]NMU观察在雄性cynomolgus猴胰岛中的蓄积和其他组织中的分布,并观察给与35或75mg/kg NMU后产生的细胞毒性。[细胞毒性] Ⅰ组6只猴,静注15mg/ml NMU
Nitroso methylurea (NMU) is an N-nitroso compound with trace amounts in food. It has been reported that NMU may also be formed endogenously in human stomach. Under the experimental conditions, N-nitroso compounds have obvious biological features such as carcinogenesis, teratogenicity and mutagenesis, and are considered as a potential toxic factor in the environment. The authors observed the accumulation in the cynomolgus monkey islets and the distribution in other tissues with [~ 8H-methyl] NMU and observed the cytotoxicity generated after administration of 35 or 75 mg / kg NMU. [Cytotoxicity] Six animals in group I were intravenously injected with 15 mg / ml NMU