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有资料显示肿瘤体积大小是影响放疗疗效的重要因素,宫颈癌、乳腺癌、头颈部肿瘤、恶性黑色素瘤的放疗结果已证实了这一点。为进一步探讨肿瘤体积对放疗疗效的影响,作者从基础实验到临床试验进行了全面的研究。假设形成克隆的细胞数与肿瘤体积成比例,则可以用以下公式计算出两种肿瘤的放疗控制率(Tumour Control Probability)TCP_2=TCP_1~(Vrel),Vrel是肿瘤体积之比V_2/V_1,因此只要知道两种肿瘤体积之比,即可知道两种肿瘤控制率之比。
There are data showing that tumor size is an important factor affecting the efficacy of radiotherapy, and the results of radiotherapy for cervical cancer, breast cancer, head and neck cancer, and malignant melanoma have confirmed this. To further explore the effect of tumor volume on the efficacy of radiotherapy, the author conducted a comprehensive study from basic experiments to clinical trials. Assuming that the number of cloned cells is proportional to the tumor volume, Tumour Control Probability TCP_2=TCP_1~(Vrel) can be calculated by the following formula, and Vrel is the tumor volume ratio V_2/V_1. As long as the ratio of the two tumor volumes is known, the ratio of the two tumor control rates can be known.