诱导分化疗法与肿瘤化疗不同,它用化学物质使分化停滞的肿瘤细胞重新分化成熟。维甲酸是第一个成功地用于治疗急性早幼粒细胞白血病(APL)的诱导分化剂。我们用全反式维甲酸(RA)治疗17例APL,其中3例用维胺酸诱导分化失败后改用RA诱导分化获得成功,这在国内外尚未见报告。临床资料与疗法一、病例 17例均为本院住院病例,按法美英(FAB)急性白血病协作组提出的分型标准确诊为APL。男8例,女9例,年龄17至50岁,平均34岁。15例单用RA治疗, Induction differentiation chemotherapy and tumor chemotherapy is different, it uses chemicals to differentiate tumor cells redifferentiated mature. Retinoic acid is the first inducer of differentiation that has been successfully used to treat acute promyelocytic leukemia (APL). We treated 17 cases of APL with all-trans retinoic acid (RA), of which 3 cases were successfully induced by the induction of differentiation with leucovorin after inducing the differentiation failure, which has not been reported at home and abroad. Clinical data and therapy First, the 17 cases were hospitalized patients in our hospital, according to the United States and Britain (FAB) acute leukemia collaborative group proposed classification criteria for the diagnosis of APL. 8 males and 9 females, aged 17 to 50 years old, with an average of 34 years old. 15 cases of RA alone treatment,