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目的:探讨外周血血清前降钙素(PCT)及C反应蛋白(CRP)的水平变化与早期诊断多器官功能障碍综合征(MODS)的关系及临床意义。方法:将106例多发伤患者按照治疗过程中有无MODS发生将患者分为MODS组和非MODS组(对照组),应用双抗夹心免疫发光法及免疫透射比浊法测定两组患者伤后6 h及第1、2、3、5、7天的血清PCT及C反应蛋白(CRP)水平,并与32例健康人群(正常组)进行对照。结果:与对照组及正常组比较,MODS组伤后6 h及第1、2、3、5、7天血清PCT均明显升高(P<0.05)。与对照组比较,MODS组伤后6h及第1、2天CRP均明显升高(P<0.05),3天后两患者组CRP比较差别无统计学意义(P>0.05)。结论:严重创伤后PCT及CRP的升高程度与继发性MODS的发生相关性高,联合测定多发伤患者外周血血清PCT及CRP含量对预测早期MODS的发生具有一定价值。
Objective: To investigate the relationship between serum levels of calcitonin (PCT) and C-reactive protein (CRP) in peripheral blood and early diagnosis of multiple organ dysfunction syndrome (MODS) and its clinical significance. Methods: 106 patients with multiple trauma were divided into MODS group and non-MODS group according to the presence or absence of MODS in the course of treatment. The double antibody sandwich immunoluminescence assay and immunoturbidimetric assay were used to determine the post-injury 6 h and 1,2,3,5,7th day serum PCT and C-reactive protein (CRP) levels, and with 32 healthy people (normal group) for control. Results: Compared with the control group and the normal group, the PCT in the MODS group was significantly increased at 6 h and 1,2,3,5,7 (P <0.05). Compared with the control group, the CRP levels of MODS group were significantly increased at 6h and 1 and 2 days after injury (P <0.05). There was no significant difference in CRP between the two groups after 3 days (P> 0.05). CONCLUSION: The elevated PCT and CRP levels after severe traumatic injury have a high correlation with the occurrence of secondary MODS. Combined detection of peripheral blood serum PCT and CRP levels in patients with multiple traumatic injuries is of great value in predicting the occurrence of early MODS.