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采用ＴＣＤ对５２３例高血压病患者与１２０例伊朗人进行对比研究，５２３例中高血压Ｉ期２２３例，Ⅱ期１６９例，Ⅲ期１３１例，各期高血压均以频谱异常率最早，其次为流通异常，再其次为ＰＩ异常。频谱异常率以ＢＡ，ＶＡ为最高，其次为前循环中的ＭＣＡ、ＡＣＡ、ＩＣＡ及ＰＣＡ，ＶＡ、ＢＡ的频谱异常率Ⅱ、Ⅲ期高于Ｉ期（Ｐ＜０．０５），ＭＣＡ、ＡＣＡ、ＩＣＡ的频谱异常率Ⅲ期明显高于Ｉ、Ⅱ期（Ｐ＜０．０１），ＢＡ、ＶＡ的频谱异常出现较早，高血压病的频谱异常以圆钝波多见，陡直波，湍流，涡流相对少见，而随病程进展，ⅡⅢ期陡直波明显高于Ｉ期（Ｐ＜０．０１），而湍流、涡流的出现率随病程进展而逐渐递增（Ｐ＜０．０１），（Ｐ＜０．０５）。血流速度的改变，各期前循环ＭＣＡ，ＡＣＡ、ＩＣＡ多以增快为主，而后循环ＶＡ、ＢＡ、ＰＣＡ流速减慢率高于增快率。
TCD 523 cases of hypertension and 120 cases of Iran were compared, 523 cases of high blood pressure in the first phase of 223 cases, 169 cases of stage Ⅱ, 131 cases of stage Ⅲ, the highest frequency of abnormalities in all spectrum frequency of the earliest, followed by Abnormal circulation, followed by abnormal PI. Spectrum abnormalities were highest in BA and VA, followed by spectrum abnormalities of MCA, ACA, ICA and PCA, VA and BA in the anterior circulation Ⅱ, Ⅲ were higher than those in stage I (P <0.05), MCA, ACA , The spectrum abnormality rate of ICA was significantly higher than that of stage I and II (P <0.01), and the spectrum abnormalities of BA and VA appeared earlier. The frequency spectrum of hypertension was more common with blunt wave, steep wave and turbulent flow (P <0.01). The incidence of turbulence and eddy current gradually increased with the course of disease (P <0.01), ( P <0.05). The change of blood flow velocity, MCA, ACA and ICA before each cycle were mainly accelerated, while the flow rate VA, BA and PCA after the cycle was higher than the rate of increase.