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聚丙交酯-乙交酯共聚物(PLG)无免疫原性,能增强包裹的破伤风类毒素(TT)的稳定性.作者用小鼠对微粒中TT的免疫原性,以及含TT的控释微粒产生的抗体的保护作用和中和能力作了评价.以溶剂蒸发技术制备微粒.选择6～8周龄体重60～80g Spragne-Dawley小鼠作实验.用微粒包裹的TT肌注小鼠,而吸附于明矾的TT肌注另组小鼠.用15Lf TT加PLG50/50或PLG100/0免疫小鼠,以比较其免疫原性.实验小鼠分为4组.第1组接
Polylactide-co-glycolide (PLG) is non-immunogenic and enhances the stability of the encapsulated tetanus toxoid (TT). The immunogenicity of TT in mice and the TT-containing control The protective effect and the neutralization ability of the antibody produced by the release microparticles were evaluated. The microparticles were prepared by the solvent evaporation technique. Sixty to eight-week-old Spragne-Dawley mice weighing 60-80 g were selected for experiment. , And another group of mice were injected intramuscularly with TT alum.The mice were immunized with 15Lf TT plus PLG 50/50 or PLG 100/0 to compare their immunogenicity.The experimental mice were divided into four groups.The first group