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脑血管疾病是危害健康的最常见疾病之一,绝经后妇女的内源性雌激素水平下降,可能引起血脂代谢障碍改变,从而可能影响脑血管疾病的发生。在实验室和动物试验中雌激素有调节血脂水平,减少动脉粥样斑块的发生,对脑血管疾病有保护作用,但一些随机对照研究提示激素替代治疗对绝经后妇女脑血管疾病可能无效或有害。由于这些研究的方法学缺陷和剂量的单一等,尚不能得出肯定的结论,对这一问题还需要深入研究和评价。
Cerebrovascular disease is one of the most common diseases that endanger the health. The decline of endogenous estrogen level in postmenopausal women may cause the disorder of lipid metabolism, which may affect the occurrence of cerebrovascular diseases. In laboratory and animal experiments, estrogen regulates blood lipid levels and reduces the incidence of atherosclerotic plaque and has protective effects on cerebrovascular disease. However, some randomized controlled studies suggest that hormone replacement therapy may not be effective for cerebrovascular diseases in postmenopausal women or harmful. Due to the methodological flaws and the single dose of these studies, no definite conclusions can be drawn yet, and further research and evaluation on this issue are needed.