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1 Hormesis现象的定义“剂量决定毒物”是16世纪著名的炼金术士及内科医生Paracelsus的名言[1],他首次将化学物质与矿物成分应用于医药治疗,并提出所有物质都是有毒的,只有剂量才能区别毒物的论点,成为毒物兴奋效应的雏形。19世纪德国微生物学家Schulz[2]观察到低浓度重金属离子可以促进酵母生长,进而认为这种现象可能普遍存在于各种化学物和生命体中,从而提出Amat-Schulz定律,即弱刺激加速生命力,中等强度刺
1 Definition of the Hormesis Phenomenon “DOSE DETERMINANTS OF TOXICITY” is the famous quote of Paracelsus, a famous alchemist and physician in the 16th century [1], who for the first time applied chemical substances and mineral components to medical treatment and proposed that all substances are toxic , Only the dose to distinguish toxic arguments, a prototype of the toxic effects of excitement. Schulz [2], a German microbiologist in the 19th century, observed that low concentration of heavy metal ions can promote yeast growth, and further that this phenomenon may be ubiquitous in a variety of chemicals and living organisms, and thus put forward the Amat-Schulz law, that is, weak stimulus acceleration Vitality, medium intensity thorn