论文部分内容阅读
目的:探讨新生儿血浆凝血酶原时间(prothromin time,PT)及活化部分凝血活酶时间(activated partial thrombo-plastin time,APTT)水平的临床意义。方法:将所分析对象分为早产儿及足月儿两组,早产儿组按胎龄分为<35W及≥35W两组。早产儿组及足月儿组均按不同日龄分为0～2 d,2 d～,1 w～,2 w～四组。入院24 h内行股静脉穿刺,用109 mmol/L枸橼酸钠真空采血管(枸橼酸钠与全血比例为1∶9)采血,用凝固法进行血浆PT、APTT的检测,并将早产儿组与足月儿组,<35W组与≥35W组及不同日龄组进行统计学分析。结果:早产儿组血浆PT、APTT较足月儿组明显延长,<35W组的血浆PT、APTT较≥35W组明显延长(P均<0.05);随着日龄增长,PT、APTT逐渐缩短。结论:新生儿应将PT、APTT作为常规检测项目,在防治新生儿出血,特别是早产儿的存活率及改善预后有重要意义。
Objective: To investigate the clinical significance of plasma prothrombin time (PT) and activated partial thrombo-plastin time (APTT) in neonates. Methods: The subjects were divided into two groups: premature infants and term infants. Preterm infants were divided into two groups according to gestational age of <35W and ≥35W. Premature infants and term infants were divided into four groups according to different age groups: 0 ~ 2 d, 2 d ~ 1 w ~, 2 w ~ 4. Intravenous puncture was performed within 24 h after admission. Blood samples were obtained from 109 mmol / L sodium citrate vacuum blood collection (1: 9 ratio of sodium citrate and whole blood). Plasma PT and APTT were detected by coagulation method. Children and full-term children group, <35W group and> 35W group and different age groups for statistical analysis. Results: The plasma PT and APTT in premature infants were significantly longer than those in term infants. Plasma PT and APTT in 35W group were significantly longer than those in ≥35W group (all P <0.05). The PT and APTT were gradually shortened with the increasing of age. Conclusion: Neonates should take PT and APTT as routine test items, and it is of great significance to prevent and cure neonatal hemorrhage, especially the survival rate of premature babies and improve the prognosis.