In this paper, we have carefully determined the stress zones in the Sichuan-Yunnan region with reference to the in-situ stress data of hydraulic fracturing and the inverted fault slip data by using the step-by-step convergence method for stress zoning based on focal mechanism solutions. The results indicate that the tectonic stress field in the Sichuan-Yunnan region is divided into 3 stress zones by 2 approximately parallel NNW-trending stress transi-tion belts. The area between the 2 belts is the Sichuan-Yunnan stress zone where the maximum principal stress σ1 is just in the NNW direction. The eastern boundary of Sichuan-Yunnan stress zone (the eastern stress transition belt) is basically consistent with the eastern boundary of Sichuan-Yunnan rhombic block. The western boundary of Si-chuan-Yunnan stress zone (the western stress transition belt) is not totally consistent with the western boundary of Sichuan-Yunnan rhombic block. The northern segment of the western stress transition belt extends basically along the Jinshajiang fault and accords with the western boundary of Sichuan-Yunnan rhombic block, while its southern segment does not extend along the southwestern boundary of the rhombic block, i.e., Honghe fault and converge with the eastern stress transition belt, but stretches continuously in the NNW direction and accords with the Ying-panshan fault. We therefore consider that under the combined influence from the northward motion of India Plate, the southeastward shift of east Qinghai-Xizang Plateau and the strong obstruction of South China block, the tec-tonic stress field in the Sichuan-Yunnan region might not be totally controlled by the previous tectonic frame and new stress transition belt may have possibly formed. In this paper, we have carefully determined the stress zones in the Sichuan-Yunnan region with reference to the in-situ stress data of hydraulic fracturing and the inverted fault slip data by using the step-by-step convergence method for stress zoning based on focal mechanism solutions. The results indicate that the tectonic stress field in the Sichuan-Yunnan region is divided into 3 stress zones by 2 approximately parallel NNW-trending stress transi-tion belts. The area between the 2 belts is the Sichuan-Yunnan stress zone where the maximum principal stress σ1 is just in the NNW direction. The eastern boundary of Sichuan-Yunnan stress zone (the eastern stress transition belt) is basically consistent with the eastern boundary of Sichuan-Yunnan rhombic block. The western boundary of Si-chuan -Yunnan stress zone (the western stress transition belt) is not totally consistent with the western boundary of Sichuan-Yunnan rhombic block. The northern segment of the western stress transition be lt extends substantially along the Jinshajiang fault and accords with the western boundary of Sichuan-Yunnan rhombic block, while its southern segment does not extend along the southwestern boundary of the rhombic block, ie, Honghe fault and converge with the eastern stress transition belt, but stretches continuously in the NNW direction and accords with the Ying-panshan fault. We therefore consider that the combination of the northward motion of India Plate, the southeastward shift of east Qinghai-Xizang Plateau and the strong obstruction of South China block, the tec-tonic stress field in the Sichuan-Yunnan region might not be totally controlled by the previous tectonic frame and new stress transition belt may have formed.