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慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)是严重危害人民身体健康的重要呼吸系统疾病[1]。COPD合并营养不良的发病率高,营养不良作为预后的独立危险因子,在COPD康复中已引起广泛注意,但因病程长,经济负担重,使治疗困难。根据大鼠饲料蛋白质含量20%～24%,低于8%为低蛋白饲料[2],设置24%和8%两个蛋白质摄入水平。按实验动物饲料配比经典方法,用酪蛋白作为蛋白质来源。观察蛋白质摄入水平对肺气肿膈肌功能形态的影响;不同水平蛋白质摄入联合中药对肺气肿大鼠膈肌功能形态的影响。探索COPD营养不良的预防和治疗措施。
Chronic obstructive pulmonary disease (COPD) is an important respiratory disease that seriously affects people’s health [1]. COPD combined malnutrition incidence, malnutrition as an independent prognostic risk factor in the recovery of COPD has attracted wide attention, but because of long duration, heavy economic burden, making treatment difficult. According to rat feed protein content of 20% to 24%, less than 8% of low protein feed [2], set 24% and 8% of the two protein intake levels. According to the experimental animal feed ratio classic method, with casein protein source. The effect of protein intake on the functional morphology of the emphysematous diaphragm was observed. The effects of different levels of protein on the diaphragmatic muscle function in emphysema rats were observed. Explore the preventive and curative measures for malnutrition in COPD.