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目的：研究血管紧张素转换酶抑制剂（ＡＣＥＩ）培哚普利和血管紧张素Ⅱ的Ⅰ型受体（ＡＴ１）拮抗剂洛沙坦对肿瘤坏死因子（ＴＮＦ）α刺激的心肌细胞间粘附分子－１（ＩＣＡＭ－１）表达的影响。 方法：运用流式细胞仪观察培养的乳鼠心肌细胞ＩＣＡＭ－１的表达量。 结果：ＴＮＦ－α可明显增加心肌细胞ＩＣＡＭ－１的表达量。从时间变化看，以刺激６ 小时表达量最高，但随作用时间延长表达量减少。培哚普利（１０－ ６ ｍ ｏｌ／Ｌ，１０－ ８ ｍ ｏｌ／Ｌ）和洛沙坦（１０－ ６ ｍ ｏｌ／Ｌ，１０－ ８ ｍ ｏｌ／Ｌ）均可明显抑制ＴＮＦ－α刺激的心肌细胞ＩＣＡＭ－１ 的表达量。 结论：培哚普利和洛沙坦均可抑制培养的心肌细胞因子ＴＮＦ－α诱导而上调的ＩＣＡＭ－１ 的表达，这可能是ＡＣＥＩ和ＡＴ１受体拮抗剂治疗心力衰竭时的心脏保护效应的重要原因
OBJECTIVE: To investigate the effects of losartan on the expression of tumor necrosis factor alpha (TNF-alpha) -expressing cardiomyocyte intercellular adhesion molecule-1 (AT1), an angiotensin converting enzyme inhibitor (ACEI) -1 (ICAM-1) expression. Methods: The expression of ICAM-1 in neonatal rat cardiomyocytes was observed by flow cytometry. Results: TNF-α significantly increased the expression of ICAM-1 in cardiomyocytes. Change from time to time to stimulate the maximum expression of 6 hours, but with the extension of time decreased expression. Perindopril (10-6 mol / L, 10-8 mol / L) and losartan (10-6 mol / L, 10-8 mol / L) significantly inhibited TNF-α stimulation Of cardiomyocytes ICAM-1 expression levels. CONCLUSION: Both perindopril and losartan can inhibit the upregulation of ICAM-1 expression induced by cultured cardiomyocyte cytokine TNF-α, which may be important for the cardioprotective effects of ACEI and AT1 receptor antagonists in the treatment of heart failure the reason