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为了解尿路感染伴有高钙尿时,后者对尿中庆大霉素抗菌活性是否有影响,作者用含庆大霉素及不同浓度Ca 的尿液对大肠杆菌和绿脓杆菌作了抑菌和杀菌试验。由临床患者尿采样培养得10株大肠杆菌和10株绿脓杆菌,另收集6名健康人的24 h 尿样,调节至pH 6,渗透压720 mosm/l,肌酐130 mg/dl,测得其离子浓度(mg/dl)为:Na 16,K 4,Ca 11,P 47和Mg 13将。10~5cfu/ml 细菌接种于MH 培养基,双倍稀释法测定庆大霉素的MIC。选用含庆大霉素50 μg/ml 的尿液作杀菌曲线,此浓度相当于常规给药时庆大霉素平均尿浓度,
In order to understand urinary tract infection associated with hypercalciuria, the latter on the urinary gentamicin antibacterial activity whether the impact, the author with gentamicin and different concentrations of urine Ca of Escherichia coli and Pseudomonas aeruginosa made Bacteriostatic and bactericidal tests. 10 strains of Escherichia coli and 10 strains of Pseudomonas aeruginosa were collected by urine sampling from clinical patients and another 24 hours of urine samples from 6 healthy individuals were collected and adjusted to pH 6 with an osmotic pressure of 720 mosm / l and creatinine 130 mg / dl The ion concentration (mg / dl) is: Na 16, K 4, Ca 11, P 47 and Mg 13 will be. 10 ~ 5cfu / ml bacteria inoculated MH medium, double dilution method for the determination of gentamicin MIC. Selection of gentamicin containing 50 μg / ml of urine for bactericidal curve, the concentration equivalent to the average administration of gentamicin average urinary concentration,