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本文用透射电镜观察大鼠胚胎发育中肝贮脂细胞的超微结构,并认为大鼠肝贮脂细胞来源于间充质细胞。伴随胚胎发育,贮脂细胞逐渐变小,到出生时尤为明显。10～12天胚胎肝贮脂细胞粗面内质网已发育,游离核糖体丰富,在狄氏隙内可见到胶原原纤维,说明这时贮脂细胞有合成胶原蛋白的功能。13～15天胚胎的少数贮脂细胞内有脂滴,同时可见滑面小管、吞饮现象和糖原颗粒。贮脂细胞与肝细胞之间存在桥粒连接。在16～18天胚胎,贮脂细胞与内皮细胞之间也有桥粒连接,说明贮脂细胞通过细胞连接与肝细胞和内皮细胞紧密连接。这时的贮脂细胞内还可见到微丝、微管,它们除了作为细胞骨架外,可能与调节血窦大小有关。在胚胎发育过程中,含脂滴的贮脂细胞和脂滴数量未见明显增加。
In this paper, the ultrastructure of hepatic steatosis cells in rat embryos was observed by transmission electron microscopy, and the hepatic steatosis cells in rat liver were derived from mesenchymal cells. With the development of embryos, the fat-storing cells gradually become smaller, especially at birth. 10 to 12 days embryonic liver fat storage cells rough endoplasmic reticulum has been developed, rich in free ribosomes, collagen fibers can be seen in the Dixie gap fibrils, indicating that the storage of fat cells have the function of collagen synthesis. 13 to 15 days embryo fat droplets in a small number of lipid cells, while visible slip surface tubules, swallowing phenomenon and glycogen particles. Desmosomes exist between the fat-storing cells and the hepatocytes. In the 16-18 day embryo, there is also a desmosome connection between the fat-storing cells and the endothelial cells, indicating that the fat-storing cells are tightly connected to the hepatocytes and the endothelial cells by cell ligation. Fibrous cells at this time can also be seen in microfilaments, microtubules, in addition to their cytoskeletal, may be related to regulating the size of sinusoids. There was no significant increase in the number of lipid-storing cells and lipid droplets containing lipid droplets during embryonic development.