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目的探讨产前应用地塞米松对早产儿水电解质平衡的影响。方法 2009年1月至2010年6月本院新生儿重症监护病房(NICU)收治的早产儿60例,观察组和对照组各30例,观察组早产儿母亲产前应用地塞米松,对照组早产儿母亲产前未应用地塞米松。测定两组血清电解质、液体出入量及体重变化,估算不显性失水量。结果观察组不显性失水量为(25.3±7.9)g,对照组为(32.7±9.3)g,两组差异有统计学意义(t=3.33,P<0.05)。两组尿量、血清钠、钾、钙、镁、氯离子浓度比较,差异无统计学意义(P均>0.05)。结论母亲产前应用地塞米松治疗可减少新生儿不显性失水量,对血电解质无明显影响。
Objective To investigate the effect of prenatal dexamethasone on the electrolyte balance in preterm infants. Methods From January 2009 to June 2010, 60 preterm infants admitted to the Neonatal Intensive Care Unit (NICU) in our hospital were treated with dexamethasone in the observation group and the control group. The control group Prenatal mother did not use dexamethasone prenatal. Determination of two groups of serum electrolytes, fluid intake and weight changes, estimation of insignificant water loss. Results In the observation group, the insignificant water loss was (25.3 ± 7.9) g in the control group and (32.7 ± 9.3) g in the control group. The difference between the two groups was statistically significant (t = 3.33, P <0.05). There were no significant differences in urine volume, serum sodium, potassium, calcium, magnesium and chloride ion concentrations between the two groups (all P> 0.05). Conclusion Prenatal dexamethasone treatment can reduce neonatal insignificant water loss, blood electrolytes had no significant effect.