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目的探究血清白蛋白(ALB)水平与高血压性脑出血血肿周围水肿的相关性。方法 2012年2月-2016年2月本院收治的230例高血压性脑出血患者为研究对象,依据患者血清ALB水平分为观察组(ALB≤35 g/L)与对照组(ALB>35 g/L),再将观察组分为重度组(<25 g/L)、中度组(25 g/L~30 g/L)和轻度组(30 g/L~35 g/L)。分别在入院时、入院后1 d、4 d和14 d分析不同时期的相对水肿体积指数(REI)和水肿体积变化指数(AEI),并分析血清ALB与其的相关性。结果入院后1 d时2组患者REI、AEI相比,差异均无统计学意义(P>0.05);入院后4 d和14 d时,观察组的REI、AEI均高于对照组,差异有统计学意义(P<0.05)。随着观察组病情的加重,患者的REI不断增加,差异有统计学意义(P<0.05)。AEI与血清ALB水平呈负相关(r=-0.738,P<0.05)。结论血清ALB水平过低会导致高血压脑出血患者的水肿程度加重,且其严重程度与血清ALB的水平呈负相关。
Objective To investigate the relationship between serum albumin (ALB) and edema around hematoma of hypertensive intracerebral hemorrhage. Methods 230 hypertensive intracerebral hemorrhage patients admitted to our hospital from February 2012 to February 2016 were enrolled in this study. According to the level of serum ALB, the patients were divided into observation group (ALB≤35 g / L) and control group (ALB> 35 (25 g / L ~ 30 g / L) and mild group (30 g / L ~ 35 g / L) . The relative edema volume index (REI) and edematous volume change index (AEI) were analyzed at admission, 1 d, 4 d and 14 d after admission, and the correlation between serum albumin and ALB was analyzed. Results There was no significant difference in REI and AEI between the two groups at 1 d after admission (P> 0.05). On the 4th and 14th day after admission, the REI and AEI in the observation group were higher than those in the control group Statistical significance (P <0.05). With the exacerbation of the observation group, the REI of the patients continued to increase, the difference was statistically significant (P <0.05). AEI was negatively correlated with serum ALB level (r = -0.738, P <0.05). Conclusion Serum ALB level is too low will lead to edema in patients with hypertensive intracerebral hemorrhage aggravated, and its severity and serum ALB levels were negatively correlated.