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目的调查天津市河东区健康人群肠道病毒71型(EV71)和科萨奇病毒A组16型(CoxA16)隐性感染状况,为手足口病的预防与控制提供依据。方法采集148名天津市河东区健康人静脉血标本进行EV71和CoxA16中和抗体测定,对检测结果进行分析。结果以抗体滴度1∶4作为临界值,调查对象EV71中和抗体阳性率为79.05%(117/148),CoxA16中和抗体阳性率为80.41%(119/148);其中,EV71中和抗体阳性率和CoxA16中和抗体阳性率最高的年龄组均为36~45岁,分别为93.10%和96.55%;0~5岁年龄组的EV71中和抗体阳性率和CoxA16中和抗体阳性率最低,分别为50.00%和46.15%。不同年龄组的EV71中和抗体阳性率和CoxA16中和抗体阳性率差异均有统计学意义(均P<0.01)。EV71和CoxA16中和抗体滴度≥1∶256的人数分别占20.95%(31/148)和16.22%(24/148)。结论人群对EV71和CoxA16普遍容易感染,健康人群中存在较高的隐性感染,因此隐性感染人群也是病原体传播的传染源之一。
Objective To investigate the latent infection status of enterovirus 71 (EV71) and CoxA16 in healthy population of Hedong District in Tianjin, and provide basis for the prevention and control of hand-foot-mouth disease. Methods A total of 148 blood samples from healthy people in Hedong District of Tianjin were collected for neutralizing antibody against EV71 and CoxA16. The detection results were analyzed. Results The antibody titer of EV71 was 79.05% (117/148), and the positive rate of neutralizing antibody of CoxA16 was 80.41% (119/148). The EV71 neutralizing antibody The positive rates of CoxA16 and neutralizing antibodies were 36-45 years old (93.10% and 96.55%, respectively). The positive rate of neutralizing antibody of EV71 and the neutralizing antibody of CoxA16 in 0-5 years old group were the lowest, Respectively 50.00% and 46.15%. The positive rate of neutralizing antibody of EV71 and the positive rate of neutralizing antibody of CoxA16 in different age groups were significantly different (all P <0.01). The numbers of EV71 and CoxA16 neutralizing antibody titer≥1: 256 were 20.95% (31/148) and 16.22% (24/148), respectively. Conclusion The population is generally susceptible to EV71 and CoxA16 infection, and there is a high prevalence of latent infection in healthy people. Therefore, the latent infection population is also one of the sources of transmission of pathogens.