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目的:来氟米特联合甲氨喋呤治疗类风湿性关节炎疗效分析。方法:将类风湿性关节炎患者随机分两组,对照组给予消炎痛25mg,3次/d,口服,同时给予强的松诱导缓解剂量0.6～0.9mg/(kg·d),缓解后逐渐减量至最小剂量,维持治疗半年。观察组给予来氟米特10mg1次/d,同时给予甲氨喋呤每周3片(2.5mg/片),维持治疗半年。结果:观察组与对照组总有效率、显效率及病情缓解时间接近,观察组复发率明显低于对照组。结论:来氟米特加甲氨喋呤治疗类风湿性关节炎疗效显著,不良反应发生较少,复发率较低。
Objective: To analyze the curative effect of leflunomide and methotrexate on rheumatoid arthritis. Methods: The patients with rheumatoid arthritis were randomly divided into two groups. The control group was given indomethacin 25 mg thrice daily for 6 days. At the same time, prednisone was given 0.6 ~ 0.9 mg / (kg · d) to relieve relief dose Reduction to the minimum dose to maintain treatment for six months. The observation group was given leflunomide 10mg once a day, meanwhile methotrexate was given 3 tablets a week (2.5mg / tablet) for six months. Results: The total effective rate, the apparent efficiency and the time to remission in the observation group and the control group were similar, and the recurrence rate in the observation group was significantly lower than that in the control group. Conclusion: Leflunomide and methotrexate are effective in the treatment of rheumatoid arthritis with fewer adverse reactions and lower recurrence rate.