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目的研究西北汉族人群HLA-A* 02等位基因的分布特点。方法对760份健康无血缘关系的西北汉族人群HLA-A* 02等位基因进行高分辨基因分型,计算HLA-A* 02各等位基因构成比并与其他不同地区人群进行比较。结果 760份样本中,检出9种HLA-A* 02等位基因,以A* 0201(48.86%)为优势等位基因,A* 0207(22.72%)和A* 0206(15.91%)比较常见,纯合子主要为A* 0201/A* 0201,杂合子主要为A* 0201/A* 0207。结论西北汉族人群HLA-A*02等位基因的分布特点比较接近北方汉族人群,但具有其自身分布特点。
Objective To study the distribution of HLA-A * 02 alleles in Northwest Han population. Methods High-resolution genotyping of HLA-A * 02 alleles in 760 healthy non-related Northwestern Han Chinese population was performed. The allelic ratios of HLA-A * 02 alleles were calculated and compared with those of other populations in different regions. Results Among the 760 samples, 9 alleles of HLA-A * 02 were detected. A * 0201 (48.86%) was the dominant allele. A * 0207 (22.72%) and A * 0206 , Homozygous mainly A * 0201 / A * 0201, heterozygous mainly A * 0201 / A * 0207. Conclusion The distribution of HLA-A * 02 allele in Northwest Han people is close to that of Han population in North China, but has the characteristics of its own distribution.