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目的 :研究二肾一夹 ( 2Ｋ1Ｃ)肾性高血压大鼠心肌肥大发生发展不同阶段Ｇｑ/ 1 1 含量与功能的变化并探讨其机制。方法 :以直径 0 2ｍｍ的银夹夹闭左侧肾动脉制备 2Ｋ1Ｃ肾性高血压大鼠模型 ,分别在术后1、2、4、8周测定尾动脉收缩压、±ｄｐ/ｄｔｍａｘ及左室舒张末压 ;测定
Objective: To investigate the changes of Gq / 1 1 content and function in different stages of cardiac hypertrophy in 2K1C rats and to explore its mechanism. Methods: 2K1C renal hypertensive rat model was established by clipping the left renal artery with a diameter of 0 2mm. The systolic blood pressure of the tail artery, ± dp / dtmax and left ventricular End-diastolic pressure; determination