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目的 探讨子宫内膜异位症 (内异症 )与人类白细胞抗原 (HLA)之间的易感相关性。方法 采用微量淋巴细胞毒试验法 ,对经手术证实为内异症的 40例患者 (内异症组 )及无内异症的 5 0例正常妇女 (对照组 )进行HLA Ⅰ类抗原的A、B位点多态性检测。内异症组和对照组均为无血缘关系的湖南、江西籍汉族妇女。结果 在HLA Ⅰ类抗原A位点上 ,两组抗原频率差异无显著性 (P>0 0 5 )。在HLA Ⅰ类抗原B位点上 ,内异症组的HLA ⅠB46抗原频率为 33% ,对照组为 16 % ,相对危险率 (RR)为 2 5 2 78,两组比较 ,差异有显著性 (P <0 0 5 ) ;内异症组的HLA ⅠB48抗原频率为 3% ,对照组为 16 % ,RR为 0 134 6 ,两组比较 ,差异亦有显著性 (P <0 0 5 )。结论 内异症的发生与HLA ⅠB46抗原存在关联 ,HLA ⅠB48抗原可能对内异症的发生有拮抗作用
Objective To investigate the susceptibility of endometriosis (endometriosis) to human leukocyte antigen (HLA). Methods A total of 40 patients with endometriosis (endometriosis group) and 50 normal women without endometriosis (control group) B-site polymorphism detection. Endometriosis group and control group are unrelated Hunan, Jiangxi Han women. Results There was no significant difference in the frequency of antigen between HLA class I and HLA class A loci (P> 0.05). HLA class I B46 antigen frequency was 33% in the group of HLA class I antigen and 16% in the control group, with a relative risk (RR) of 2 5 2 78. There was significant difference between the two groups P <0.05). The frequency of HLA-B48 antigen in endometriosis group was 3%, in control group was 16%, RR was 0 134 6, the difference was also significant (P <0.05). Conclusions The occurrence of endometriosis is associated with HLA Ⅰ B46 antigen. HLA Ⅰ B48 antigen may be antagonistic to the occurrence of endometriosis