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The pathogenic mechanisms underlying Batten disease are unclear. Patients unif ormly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome.Batten patien ts did not possess autoantibodies against other type 1 diabetes-associated auto antigens and human leukocyte antigen genotypes revealed no specific associations with this disease.
The pathogenic mechanisms underlying Batten disease are unclear. Patients unif ormly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome Patten patien ts did not possess autoantibodies against other type 1 diabetes-associated auto antigens and human leukocyte antigen genotypes revealed no specific associations with this disease.