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目的了解湖北省近几年抗病毒治疗工作的开展情况,以评价湖北省抗病毒治疗状况及效果。方法通过调查艾滋病病人治疗率、服药依从性率及基线和治疗后1～3年CD4+T淋巴细胞变化情况反映抗病毒治疗效果。结果4个项目县的平均治疗率从2005年的43.11%上升到2008年底的72.77%。督导服药覆盖率都在98%以上,但随州、浠水、南漳、巴东的4年平均服药依从率分别为87.6%,99.7%,91.0%和70.3%,不同项目县的4年平均服药依从率差异有统计学意义。经过抗病毒治疗后,患者的CD4水平升高,而且呈现逐年升高的趋势。结论抗病毒治疗提高了患者的CD4水平,但上升趋势逐年减弱。长期抗病毒治疗迫切需要加强和落实患者的服药依从性教育和督导。
Objective To understand the development of antiviral therapy in Hubei Province in recent years to evaluate the status and effect of antiviral therapy in Hubei Province. Methods The therapeutic effect of antiviral therapy was investigated by investigating the treatment rate of AIDS patients, the medication adherence rate and the change of CD4 + T lymphocytes at baseline and 1-3 years after treatment. Results The average treatment rate of 4 project counties increased from 43.11% in 2005 to 72.77% at the end of 2008. The coverage rate of supervising medication was above 98%, but the average medication adherence rates in Suizhou, Xishui, Nanzhang and Badong in 4 years were 87.6%, 99.7%, 91.0% and 70.3% respectively. The average medication in 4 years in different counties Compliance rates were statistically significant. After antiviral therapy, patients with CD4 levels increased, but also showed an upward trend year by year. Conclusion Antiviral therapy increased the CD4 level in patients, but the increasing trend declines year by year. Long-term antiviral treatment There is an urgent need to strengthen and implement medication adherence education and supervision of patients.