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AIM:To analyse the role of genetic susceptibility andenvironmental factors in the process of esophageal cancer(EC) formation in Xi’an,China.METHODS:A hospital based case-control study,combinedwith molecular epidemiological method,was carried out.Atotal of 127 EC cases and 101 controls were interviewedwith questionnaires containing demographic items,habit oftobacco smoking,alcohol drinking,and family history of EC.Polymorphism of CYP1A1 and GSTM1 of 127 EC cases and101 controls were detected by PCR method.The interactionsbetween genetic susceptibility and environmental factorswere also discussed.RESULTS:Tobacco smoking,alcohol drinking and a familyhistory of EC were risk factors for EC with an OR of 2.04(95% CI 1.15-3.60),3.45(95% CI 1.74-6.91),3.14 (95%CI 1.28-7.94),respectively.Individuals carrying CYP1A1Val/Val genotype compared to those with CYP1A1 Ile/Ilegenotype had an increased risk for EC (OR 3.35,95% CI1.49-7.61).GSTM1 deletion genotype was a risk factor forEC (OR1.81,95% CI 1.03-3.18).Gene-environment interactionanalysis showed that CYP1A1 Val/Val genotype,GSTM1deletion genotype had synergetic interactions with tobaccosmoking,alcohol drinking and family history of EC.CONCLUSION:Tobacco smoking,alcohol drinking and afamily history of EC are risk factors for EC.CYP1A1 Val/Valand GSTM1 deletion genotypes are genetic susceptibilitybiomarkers for EC.There are synergic interactions betweengenetic susceptibility and environmental factors.
AIM: To analyze the role of genetic susceptibility andenvironmental factors in the process of esophageal cancer (EC) formation in Xi’an, China. METHODS: A hospital based case-control study, combinedwith molecular epidemiological method, was carried out. Atotal 127 EC cases and 101 controls were interviewed questionnaires containing demographic items, habit of tobacco smoking, alcohol drinking, and family history of EC. Polymorphisms of CYP1A1 and GSTM1 of 127 EC cases and 101 controls were detected by PCR method reaction of PCR method. The interaction between genetic susceptibility and environmental factors also more (95% CI 1.74-6.91), 3.14 (95% CI 1.28- 7.94), respectively.Individuals carrying CYP1A1Val / Val genotype compared to those with CYP1A1 Ile / Ilegenotype had an increased risk for EC (OR 3.35,95% CI1.49-7.61). GSTM1 deletion genotype was a risk factor forEC (OR1.81 , 95% CI 1. 03-3.18). Gene-environment interaction analysis showed that CYP1A1 Val / Val genotype, GSTM1 deletion genotype had synergetic interactions with tobaccosmoking, alcohol drinking and family history of EC. CONCLUSION: Tobacco smoking, alcohol drinking and afamily history of EC are risk factors for EC .CYP1A1 Val / Valand GSTM1 deletion genotypes are genetic susceptibility biomarkers for EC.There are synergic interactions between genetic susceptibility and environmental factors.