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目的本文中孕期母血清21三体综合征产前筛查工作,分别采用VICTOR2 D 1420分析仪、AutoDELFIA 1235分析仪检测,分别用2T-Risk软件、Life Cycle软件评估胎儿21-三体综合征风险,并对两种检测系统数据进行比较。方法对21 997例孕15~20+6w的孕妇采用VICTOR2 D 1420分析仪与AutoDELFIA 1235分析仪检测孕妇血中的AFP、β-HCG和uE3浓度,以及相应的2T-Risk和Life Cycle软件评估软件计算21三体综合征危险值,并对两种检测系统数据进行比较。结果 VICTOR2 D 1420组11882例孕妇中筛查出21-三体高风险99例,占0.83%,其中2例确诊,1例假阴性,检出率67%;AutoDELFIA 1235组10 115例孕妇中筛出21-三体高风险329例,占3.25%,其中5例确诊,1例假阴性,检出率83%。结论 VICTOR2 D 1420分析仪与AutoDELFIA 1235两种检测系统都可用于中孕期母血清产前筛查21三体综合征,对于降低出生缺陷有重要作用,但比较发现AutoDELFIA 1235对孕中期母血清21-三体综合征产前筛查有更高的检出率。
Objective In this paper, maternal serum 21 trisomy 21 prenatal screening work, respectively, using VICTOR2D1420 analyzer, AutoDELFIA 1235 analyzer, respectively, with 2T-Risk software, Life Cycle software to assess the risk of fetal trisomy 21 , And compare the two detection system data. Methods 21,997 pregnant women with gestational age 15-20 + 6w were tested for the levels of AFP, β-HCG and uE3 in pregnant women by VICTOR2 D 1420 analyzer and AutoDELFIA 1235 analyzer, and the corresponding softwares for evaluating 2T-Risk and Life Cycle software Calculate the trisomy 21 risk values and compare the two test system data. Results Among 11 882 pregnant women in VICTOR2 D 1420 group, 99 cases were high risk of trisomy 21, accounting for 0.83%, of which 2 were diagnosed and 1 was false negative, with a detection rate of 67%. Of 10 115 pregnant women with AutoDELFIA 1235, 21 - Three high risk 329 cases, accounting for 3.25%, of which 5 were diagnosed, 1 case of false negative, the detection rate of 83%. Conclusion VICTOR2 D 1420 analyzer and AutoDELFIA 1235 two detection system can be used for prenatal screening of maternal serum trisomy 21, plays an important role in reducing birth defects, but compared AutoDELFIA 1235 of the second trimester maternal serum 21- Prenatal screening trisomy syndrome has a higher detection rate.