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目的了解人乳头瘤病毒(HPV)在浙江省丽水市人民医院妇科门诊就诊患者中的感染情况及其亚型分布。方法应用基因芯片技术对2006年10月至2007年6月在该院就诊的246例患者进行HPV23种基因型检测。结果246例患者中共检出HPV阳性者125例,阳性率为50.8%,其中HPV-16型54例(阳性率为21.9%),HPV-58型21例(阳性率为8.5%),其余型别为50例(阳性率为20.3%),2种型别以上HPV阳性39例(阳性率为15.8%),单种型别HPV阳性86例(阳性率35.0%)。同时,在55例宫颈上皮内瘤变(CIN)患者中HPV阳性39例(阳性率70.9%),在12例宫颈癌中HPV阳性11例(阳性率91.7%),在13例宫颈尖锐湿疣中HPV阳性11例(阳性率84.6%)。结论应积极控制HPV感染及有效治疗CIN在妇女宫颈癌的防治中具有重要意义。
Objective To understand the infection status and subtypes of human papillomavirus (HPV) in gynecology outpatient department of Lishui People’s Hospital of Zhejiang Province. Methods Genomic microarray technique was used to detect HPV23 genotypes in 246 patients treated in this hospital from October 2006 to June 2007. Results A total of 125 HPV positive cases were detected in 246 patients (50.8%), of which 54 were HPV-16 (21.9% positive) and 21 were HPV-58 (8.5% positive) Fifty cases (positive rate was 20.3%) were HPV positive in two types and 39 cases (positive rate was 15.8%). The positive rate of HPV was 86% (positive rate 35.0%). At the same time, in 55 cases of cervical intraepithelial neoplasia (CIN), 39 were positive for HPV (positive rate was 70.9%), 11 were positive for HPV (91.7%) in 12 cases of cervical cancer, and in 13 cases of cervical condyloma acuminatum HPV positive in 11 cases (positive rate 84.6%). Conclusion HPV infection should be actively controlled and effective treatment of CIN in the prevention and treatment of cervical cancer in women is of great significance.